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Organic compounds that contain one or more carbonyl (a carbon atom with a double bond to an oxygen atom) functional groups. Includes compounds with functional groups that contain a carbonyl in their structure such as ketones, aldehydes, and others.
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SPR719 (VXc-486) is an orally active gyrase B inhibitor with bactericidal activity. It shows promise for research into lung disease caused by non-tuberculous mycobacteria (NTM). It potently inhibits multiple agent-sensitive and drug-resistant isolates of *Mycobacterium tuberculosis*.
Potently inhibits *Mycobacterium tuberculosis*
Active against agent-sensitive and drug-resistant isolates
Promising for research into lung disease caused by non-tuberculous mycobacteria
Inhibits *M. tuberculosis* replication in macrophages
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3-Bromopyruvic acid (CAS 1113-59-3) abbreviated as 3-BP is a small molecule inhibitor that targets hexokinase II (HK2) an enzyme notably upregulated in cancerous cells By inhibiting HK2 activity (Ki 2 4 mM) 3-BP interferes with glycolytic energy metabolism leading to reduced tumor cell proliferation in hepatocellular carcinoma BEL-7402 cells In mouse xenograft models of hepatocellular carcinoma administration of 3-BP (50 mg/kg/day six days weekly for three weeks) results in decreased tumor growth and increased tumor necrosis This compound serves as a tool in oncology research particularly for studying glycolysis-dependent tumor metabolism
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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3-Campholenyl-2-butanol is a synthetic sandalwood odorant that acts as a selective olfactory receptor OR2AT4 agonist. It has been shown to prolong human hair growth ex vivo by reducing apoptosis and enhancing the production of the anagen-prolonging growth factor IGF-1 within the outer root sheath (ORS). In vitro studies indicate that it retards spontaneous hair follicle (HF) regression (catagen development) ex vivo and significantly reduces apoptosis in hair matrix keratinocytes.
Synthetic sandalwood odorant
Selective olfactory receptor OR2AT4 agonist
Prolongs human hair growth ex vivo
Reduces apoptosis in hair matrix keratinocytes
Enhances IGF-1 production in outer root sheath
Retards spontaneous hair follicle regression ex vivo
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(S)-(-)-Propranolol hydrochloride is a chiral antihypertensive agent with approximately 100-fold higher potency than its R-enantiomer. It is used for studies on hypertension, angina pectoris, and arrhythmia. It appears as a white to off-white solid.
Chiral antihypertensive agent
Approximately 100-fold higher potency than its R-enantiomer
Can be used for studies on hypertension, angina pectoris, and arrhythmia
Exhibits enantiospecific SERS spectral features and peak intensity ratios when analyzed using an NPGB/EC-SERS platform, enabling label-free chiral differentiation
For research use only
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